Role for CD47-SIRP signaling in xenograft rejection by macrophages
نویسندگان
چکیده
*Department of Surgery, Division of Frontier Medical Science, Programs for Biomedical Research, Graduate School of Biomedical Science, Hiroshima University, Hiroshima 734-8551, Japan; †Bone Marrow Transplantation Section, Transplantation Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02129; and ‡Neuroprotection Research Laboratory, Department of Radiology and Neurology, Massachusetts General Hospital, and Program in Neuroscience, Harvard Medical School, Boston, MA 02129
منابع مشابه
Biological Science / Medical Science Role for CD47-SIRP signaling in xenograft rejection by macrophages
We have previously proven that human macrophages can phagocytose porcine cells even in the absence of antibody or complement opsonization, indicating that macrophages present a pivotal immunological obstacle to xenotransplantation. A recent report indicates that the signal regulatory protein (SIRP) is a critical immune inhibitory receptor on macrophages, and its interaction with CD47, a ligand ...
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Signal regulatory protein alpha (SIRPalpha) is a critical immune inhibitory receptor on macrophages, and its interaction with CD47, a ligand for SIRPalpha, prevents autologous phagocytosis. We hypothesized that interspecies incompatibility of CD47 may contribute to the rejection of xenogeneic cells by macrophages. Here, we show that pig CD47 does not interact with mouse SIPRalpha. Similar to CD...
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